Which substances are known to inhibit prolactin secretion? (Choose 2)

Dopamine is well-known as a primary inhibitor of prolactin secretion. It acts as a prolactin-inhibiting factor (PIF), which is important in maintaining the hormonal balance within the body. In the hypothalamus, dopamine is secreted by dopaminergic neurons and travels to the anterior pituitary gland, where it inhibits the release of prolactin. This regulatory mechanism is crucial because prolactin is involved in various physiological functions, including lactation and reproductive health.

While serotonin may play a role in various neurological and physiological processes, it does not have a significant inhibitory effect on prolactin secretion compared to dopamine. Therefore, the focus on dopamine as a key regulatory substance emphasizes its role as a brake on prolactin release, while other substances like ACTH do not have a direct inhibitory influence on prolactin secretion.

Thus, identifying dopamine is vital for understanding hormone regulation and its physiological implications.