Which region of the adrenal gland cortex produces Cortisol?

The region of the adrenal gland cortex responsible for producing cortisol is the zona fasciculata. This layer is located between the zona glomerulosa, which produces mineralocorticoids such as aldosterone, and the zona reticulata, which primarily produces androgens.

Cortisol is a glucocorticoid hormone that plays a vital role in metabolism, the immune response, and stress reactions. The zona fasciculata consists of large cells arranged in columns, which facilitates the enzymatic processes involved in cortisol synthesis. The production of cortisol is stimulated by adrenocorticotropic hormone (ACTH) released from the anterior pituitary.

The other regions of the adrenal cortex have distinct functions that do not include the production of cortisol, making it clear why the correct choice is the zona fasciculata.