Which receptors would most likely be associated with glaucoma when they are stimulated? (Choose 2)

In the context of glaucoma, the focus is on how certain receptors influence intraocular pressure and aqueous humor dynamics. The correct answer involves Alpha 1 and Beta 2 receptors.

Alpha 1 receptors, when stimulated, can lead to vasoconstriction and increased resistance to aqueous humor drainage, which can contribute to elevated intraocular pressure, a key factor in glaucoma. This receptor's activation in the eye can potentially hinder the outflow of aqueous humor, exacerbating the condition.

Beta 2 receptors, on the other hand, are generally involved in promoting relaxation of smooth muscle and can facilitate increased outflow of aqueous humor through the trabecular meshwork. Their activation can help lower intraocular pressure by enhancing the drainage pathways of the eye.

In combination, stimulation of Alpha 1 receptors might aggravate glaucoma due to increased pressure, while Beta 2 stimulation could counteract this effect by promoting aqueous humor outflow and reducing intraocular pressure. Therefore, the association of Alpha 1 and Beta 2 receptors with glaucoma relates directly to their respective roles in regulating intraocular pressure through different mechanisms.