Which physiological event usually follows the increase of renin secretion?

When there is an increase in renin secretion, it typically initiates a cascade of physiological events culminating in the release of aldosterone. Renin, an enzyme produced by the juxtaglomerular cells of the kidneys, is secreted in response to low blood pressure, decreased sodium chloride concentration, or sympathetic nervous system stimulation.

Once renin is released, it acts on angiotensinogen, a precursor protein produced by the liver, converting it into angiotensin I. Angiotensin I is then converted to angiotensin II, primarily in the lungs, through the action of angiotensin-converting enzyme (ACE). Angiotensin II has several important physiological effects, one of which is stimulating the adrenal cortex to release aldosterone. Aldosterone, a steroid hormone, promotes sodium retention and potassium excretion in the kidneys, leading to increased reabsorption of water, ultimately raising blood volume and blood pressure.

Recognizing this sequence of events highlights the critical role of renin in the regulation of blood pressure and fluid balance within the body, linking it directly to the physiological event of aldosterone release.