Which method accounts for about 90% of CO2 transport from tissues to lungs?

Prepare for the NBEO General Physiology Exam. Study with detailed flashcards and multiple choice questions, each with explanations. Ensure success on your exam!

The majority of carbon dioxide (CO2) transport from the tissues back to the lungs occurs in the form of bicarbonate. When CO2 is produced in the tissues, it diffuses into red blood cells, where it is converted to bicarbonate (HCO3-) through a reaction catalyzed by the enzyme carbonic anhydrase. This reaction involves CO2 combining with water to form carbonic acid (H2CO3), which quickly dissociates into bicarbonate and hydrogen ions.

Once bicarbonate is formed, it is transported in the plasma to the lungs, where it can re-enter red blood cells and convert back into CO2, allowing for its exhalation. This bicarbonate formation effectively facilitates the removal of CO2 from tissues, accounting for approximately 90% of total CO2 transport in the bloodstream.

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