Which hypothalamic hormone stimulates the synthesis and release of Growth Hormone?

Growth Hormone Releasing Hormone (GHRH) is the hypothalamic hormone responsible for stimulating the synthesis and release of Growth Hormone (GH) from the anterior pituitary gland. GHRH acts by binding to specific receptors on the somatotropic cells of the pituitary, promoting the secretion of GH. This hormone plays a crucial role in regulating growth, metabolism, and body composition by stimulating growth in tissues and promoting protein synthesis.

GHRH is released in response to various stimuli, including hypoglycemia, sleep, stress, and exercise, thereby ensuring that GH levels are appropriately regulated according to the body's needs. This regulatory mechanism is essential for growth during childhood and adolescence, as well as for maintaining tissue health and metabolism in adulthood.

The other hormones listed do not have a primary role in stimulating the release of Growth Hormone. For instance, Thyrotropin Releasing Hormone (TRH) is involved in stimulating the release of Thyroid Stimulating Hormone (TSH), and Adrenocorticotropic Hormone (ACTH) primarily stimulates cortisol release from the adrenal glands. Prolactin Releasing Hormone is associated with the regulation of prolactin, which plays roles in lactation rather than growth