Which diuretic acts primarily on the Distal Convoluted Tubule?

The thiazide diuretic is known for its primary action on the Distal Convoluted Tubule (DCT) of the nephron in the kidneys. These diuretics work by inhibiting the sodium-chloride symporter located in the DCT, which reduces the reabsorption of sodium and chloride ions. As a result, water follows the solutes, leading to an increase in urine output and a decrease in blood volume, which can effectively lower blood pressure.

In contrast, loop diuretics target the ascending loop of Henle, which is a different segment of the nephron. Potassium-sparing diuretics typically act on the collecting ducts and late distal tubules, and carbonic anhydrase inhibitors primarily affect the proximal convoluted tubule. Thus, the thiazide diuretic stands out for its specific action on the Distal Convoluted Tubule, making it the correct choice for this question.