Which anterior pituitary hormone has a diabetogenic effect that decreases glucose entry into cells?

The hormone with a diabetogenic effect that decreases glucose entry into cells is Growth Hormone (GH). This effect can be explained by GH's role in promoting lipolysis and increasing blood glucose levels through various mechanisms. When GH is secreted, it acts on adipose tissue to break down fats, releasing free fatty acids into the bloodstream. This process allows the body to utilize fats as a primary energy source rather than glucose.

Furthermore, GH antagonizes the action of insulin, which is the hormone responsible for facilitating the uptake of glucose into cells. By inhibiting insulin's effectiveness, GH leads to increased plasma glucose levels as cells become less responsive to insulin. This decreased sensitivity contributes to a state that resembles insulin resistance, which is a characteristic of diabetes.

In contrast, the other hormones listed—Adrenocorticotropic Hormone (ACTH), Thyroid Stimulating Hormone (TSH), and Luteinizing Hormone (LH)—do not have a direct diabetogenic effect. ACTH primarily stimulates cortisol production from the adrenal cortex, TSH regulates thyroid hormone production, and LH is involved in reproduction processes such as ovulation and testosterone production. While corticosteroids (which are stimulated by ACTH) can lead to increased blood glucose levels