What hormone inhibits the release of both GH and TSH?

Somatostatin plays a crucial role in the body's hormonal regulation by inhibiting the release of several hormones, including growth hormone (GH) and thyroid-stimulating hormone (TSH). It is secreted by the delta cells of the islets of Langerhans in the pancreas, as well as in the hypothalamus and gastrointestinal tract. By acting within the hypothalamus, somatostatin effectively suppresses the production and release of GH from the anterior pituitary and also inhibits the secretion of TSH, which regulates thyroid function.

This inhibition occurs as somatostatin binds to specific receptors on cells that produce GH and TSH, leading to a decrease in their secretion. Understanding the role of somatostatin is important when exploring the feedback mechanisms that control hormone levels in the body, particularly in relation to growth and metabolism.